Endocrine Abstracts

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objetives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted to the area of Vascular Surgery and Angiology (VS).Material and methods: Descriptive analysis of patients admitted to the VS Service who presented abnormally high or decreased bloo...

The emergence of a new generation of long-acting insulin analogues (insulin degludec -ID- and insulin glargine 300 U/ml -IG300-) has increased treatment options in type 1 diabetes (T1D), demonstrating in clinical trials better metabolic control with lower hypoglycemia rates.Objectives: To assess characteristics of T1D patients who were given ID and IG300 in clinical practice and to evaluate their effect on metabolic control, weight, insulin dose and hypo...

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...

Pituitary ACTH-secreting tumour presents with variety of clinical features: normal cortisol secretion and ACTH-immunopositive staining and mild hypercortisolism without typical features of Cushing’s disease. We present a 53-year-old male with history of hypertension. First visit (2005): visual loss, bitemporal hemianopsia in campimetry and in MRI pituitary adenoma (2.5 cm) invading cavernous sinus and suprasellar cister. Hormonal study supported panhypopituitarism. After ...

Introduction: Oncocytomas are tumours composed by oncocytes, cells with granular and eosinophilic cytoplasm filled with mitochondria. It is a neoplasm that can arise in several organs (more commonly described in the kidney, salivary gland and thyroid). Oncocytoma arising in the adrenal gland is a rare finding. Most of them are benign and non-functioning and are detected incidentally. However, functional adrenal oncocytomas presenting as Cushing’s syndrome and phaeochromoc...

Introduction: Cushing’s syndrome (CS) due to macronodular adrenal hyperplasia ACTH-independent (MAHAI) is rare. Regulation of cortisol secretion by G-protein-coupled receptors (GPCRs) aberrantly expressed is frequently found in MAHAI. Various aberrant receptors have been reported, mostly: GIP, vasopressin, beta-adrenergic, LH/hCG and serotonin.Case report: 61 years old woman. Medical history: type 2 diabetes, hypertension, obesity, dyslipidaemia and...

Prevalence of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS) in female to male transsexuals (FMT) is controversial. To known the prevalence of hyperandrogenism and PCOS in FMT, and their relation with insulin resistance (IR) and other cardiovascular risk factors (CVRF), we studied 77 Spanish consecutive FMT cases, the first ones who appeared in our Gender Unit between May 2007 and Dec 2008, aged 18–43 years. The subjects had never received hormonal treatment o...

We describe the clinical case of two childbearing age women with thyroid dysfunction, hypocalcemia, hyperphosphatemia, and high levels of PTH.Case 1: A 34-year-old woman with infertility for 3 years, microprolactinoma treated with low-dose dopamine agonists, autoimmune primary hypothyroidism and obesity. She had irregular menstrual cycles and fatigue. Weight 130 kg, height 155 cm, cervical acanthosis nigricans and round face. Calcium 6.6 mg/dl, phosphoro...

Objective: To evaluate the response to treatment with insulin infusion pumps by the evolution of HbA1c over 8 years of experience.Methods: Observational retrospective study. We evaluated the response to treatment in 122 patients with type 1 diabetes recruited between 2004 and 2012 in our area.Results: Between 2004 and 2012, 122 pumps have been implemented (average of 17.4 pumps/year). The number decreased to only four in 2012. Pres...

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Clinical suspicion is determined by the severity of hyperparathyroidism associated or not with palpable cervical tumor and local invasion when surgery.Case report: A 45-year-old woman without any previous history of kidney stones or fractures. Admitted to hospital because of high hypercalcemia (calcium 15.1 mg/dl), fatigue and generalized arthralgia. Physical examination revealed right...